Under the national policy of "Non-Grain Production" for cultivated land, Jilin Province, as a major ginseng-producing region, faces the challenge of limited planting land. Exploring the comprehensive benefits of the "Ginseng-Maize" rotation system holds significant implications for the sustainable development of the industry. Based on field survey data from 97 valid samples in Ji'an City and Fusong County, Jilin Province, this study employs economic benefit analysis and the Projection Pursuit Comprehensive Evaluation Method to systematically assess the cost-benefit and integrated advantages of this rotation system. The results indicate that, compared to traditional planting practices, the“Ginseng-Maize”rotation system reduces costs per ha by 5.10%, increases maize yield by 8.94%, enhances net benefits by 56.87%, and improves the output-input ratio by 14.49%. In the comprehensive benefit evaluation, the projection value of the rotation system significantly surpasses that of conventional practices, with the“Ginseng-Maize”rotation system demonstrating the highest overall efficiency. The study demonstrates that the“Ginseng-Maize”rotation system achieves synergy between economic benefits and ecological sustainability through optimized soil physical structure, nutrient utilization and reduced production costs, providing a scientific foundation for the high-quality development of the ginseng industry in Jilin Province.