Different compound regulators were sprayed during middle to late stages to winter wheat to regulate physiology activity of the underground and aboveground.The compound Ⅰ,Ⅳ raised obviously the activity of the root system,the content of chlorophyll,the SOD activity and dropped the content of MDA and delayed the emergence of the peak of MDA.Comparing with control,the compound Ⅰ and the compound Ⅳ delayed the time that leaves changed to yellow for 2～3d and 3～4d respectively.The two compounds cound decrease the rate of physiology senescence during late stage and increased the 1000-grain-weight and the yield.