Due to sperm has special function, it has been thought as ideal vectors for introducing foreign DNA.Sperm-mediated gene transformation is the most convenient way and also has little concealed damage.It is reported that several positive animals can be obtained through the sperm-mediation.Recent advance on these researches was introduced and assessed in the paper, which covered method of transgenic animal, molecular mechanism of interact sperm and foreign DNA, foreign DNA existing form of introducing animal or embryo, factors which affected integration of sperm and foreign DNA.The development tendency of sperm as vector introducing gene into animal was predicted in the paper.