Experiment on the effect of controlling weeds with mixture of three herbicides of post-emergence with atrazine or atrazine with 2,4-D butylate was carried out in the field.The results showed that three herbicides of nicosulfuron,mesotrione and flumetslam mixed with atrazine or atrazine with 2,4-D butylate controlled weeds very well.The effect of controlling weeds with mixture of two kinds of herbicides was 92.20%,93.30% and 92.36%.The effect of controlling weeds with mixture of three kinds of herbicides was 96.43%,96.16% and 94.29%.The mixture of two or three kinds of herbicides could enlarge the control spectrum and get higher control effect.It was safe to maize growth and the yield of maize increased more than 6% than manual weeding.