Purpose of this study was researching on the changes of the content of sodium and potassium in both the blood serum and the milk from the cow which suffers the disease of alcohol-positive milk.The relationship between sodium and potassium and the cows with disease was determined and this provided the clinic treat with the scientific basis.In the experiment we tested the alcohol-positive milk by using the 68% alcohol,and tested the 68% alcohol-positive milk using use the 72% alcohol.Then we tested the 72% alcohol-positive milk using the 75% alcohol.Then cows were divided into four groups: 75% alcohol-negative（control）,75% alcohol-positive,72% alcohol-positive and 68% alcohol-positive.6 cows of the same milk production,parity,age and lactation period were selected for one group.During the following three weeks,the blood and the milk from the cows in each group were gathered the content of sodium and potassium in both the blood serum and the milk determined using the flame photometer.Results showed that the content of the sodium and potassium in blood serum in group 2,3,4 was significantly lower than that in group 1（P＜0.05）.It was concluded that in clinical treatment,we can curing the alcohol-positive milk cows by adding NaHCO₃,NaCl to the food or instilling 5% NaHCO₃ or NaCl.The stability of the milk decreased because the content of sodium and potassium decreased,but its value was not lost,so we can use it reasonably.