Experiment of controlling weeds with 13 herbicides and mixture of 7 herbicides of pre-emergence spraying was carried out on the pot-cultured maize.The results showed that the effect of controlling weeds of mixture of atrazine,acetochlor and 2,4-D butylate was 98.05%.The effect of controlling weeds of mixture of flumetsulam and acetochlor was 97.30%.The effect of controlling weeds of mixture of thifensulfuron-methyl and acetochlor was 96.98%.Through mixture of two or three kinds of herbicides could enlarge the control spectrum and get higher control effect and reduce remaining toxicity and weeding cost.It was safe to maize growth and delayed resistance of weeds to herbicide.