Effects of drought and salt compound stress on seed germination and seedling growth of sesame were studied by PEG simulated drought plus NaCl.Results of experiment showed that with the compound stress increase,seed germination and seedling growth of sesame were gradually suppressed.The compound stress of mild drought and mild salt stress（50 g.L^-1PEG + 50 mmol.L^-1NaCl） had no significantly effects on germination rate and germination index of sesame seed but had significantly effects on the germination energy,vigor index and seedling growth index value（P＜0.05）.The germination index and seedling growth index of sesame of each treatment of moderate to severe compound stress of drought and salt（150～200 g.L^-1PEG + 100～200 mmol.L^-1NaCl） were significantly lower than that of mild compound stress.