The mechanochemical method and activator（physiological acidic fertilizer- ammonium sulfate, ammonium chloride） were used to activate rock phosphate in the thesis. Besides, effect of activation equipment and used the activator on rock phosphate was investigated. This was for provide scientific basis to take full advantage of the low-grade phosphate rock in China. The results showed that the effectiveness of rock phosphate increased significantly with increasing processing times. Used activator in vibration activation equipment reduced the number of times of mechanical activation. The activation effect of using mechanically activation three times and adding 5%（NH4） 2SO4 and 10% NH4Cl was the best. The activation effect applied impingement activation equipment with activation time less than 12 min and added 10%（NH4） 2SO4, 10% NH4Cl was better. The time of mechanical activation was more than 12 min and added activator played a negative role to the increase in the rate of rock phosphate citrate acid dissolved. So the mechanical activation method should be used only.