Aims of this experiment were analyzing the control efficiency and safety of 11% metalaxyl-M,fludioxonil and azoxystrobin FS to head smut of corn. This experiment was carried out according to Guidelines for the Field Efficacy Trials of Pesticides（Ⅱ） Part 106: Fungicides against Head Smut of Corn. Results showed that it has well efficiency on controlling head smut of corn. The effect of low dose, media dose and high dose was 73.2%, 86.6% and 94.8%. The germination rate of corn increased by 4.1%~11.3%, and its root development was promoted also, so corn yield increased. 11% metalaxyl-M, fludioxonil and azoxystrobin FS should be mixed with corn seeds before sowing, and its application dose was 300 mL with 100 Kg seeds. It should be 400 mL with 100 kg seeds when the head smut was serious in field last year or the variety was susceptible to the disease.