The experiment was carried out to study the effects of different fertilizer applications on the fertilizer use efficiency and soil fertility for gobi soil cultivated Crimson Seedless grape with drip irrigation in dry region using 3414 field experiments design.The result showed that the fertilizers recovery and partial factor productivity were the highest in the N2P2K2 treatment The NPK fertilizers use efficiency were 40.12%,16.67%and 38.56%in the N2P2K2 treatment,partial factor productivity were 51.53 kg/kg,68.58kg/kg and 102.87 kg/kg in the N2P2K2 treatment.The NPK fertilizers and organic matter content showed a regular change trend at different depth of gobi soil in the N2P2K2 treatment.N,K and organic matter content before flowering were significantly higher than that after harvest.P content was higher before flowering than after harvest.In general,soil fertility of each treatment was higher after harvest than before flowering.Long-term fertilization significantly influenced gobi soil nutrient content after grape fruit harvest So for fertilizer use efficiency or to maintain soil fertility,fertilization in this region should select nitrogen phosphorus potassium complex.