The control effect of spraying in the field of different chemicals against Asian Corn Borer was studied. The results showed that 40% Chlorantraniliprole + Thiamethoxam had best control effect, which was 93.23% and 93.68% of infected rate of plants and living insect rate. Similar results were obtained in large scale demonstration test using high arm sprayer, which control effect was 92.93% and 93.22% of infected rate of plants and living insect rate. Its yield was 7.71% higher than that of control. The chemical has stomach poison and interior suction effect and low toxicity, is the rational agent for the control against Asian Corn Borer.