Regression analysis algorithm is widely used in engineering, botany and other research fields. Basedon regression analysis algorithm, a multivariate mixed model was proposed in the paper on the basis of the existingalgorithm and some improvement based on related experiment. Comparing with existing algorithms, new multivariatemixed model presented in the paper bring better drying test results and higher quality rate. The model algorithm andexperimental results made a good attempt for the study of ginseng drying algorithm, and it accumulated some experi-ence for the study of ginseng drying process.