Using AK 58 as test material and three different chemical control agents for treatments, effect ofchemical control agents on main agronomic traits and yield of wheat was studied. Results showed that spraying of Pa-clobutrazol, Duntianbao and Gibberellin effectively inhibited wheat plant height. Number of grain per ear and 1000-grains weight increased, and yield increased by 3.6%~9.8%. Among them, spraying Paclobutrazol at jointing stagesignificantly reduced the plant height of wheat, spraying Duntianbao at flowering period shortened the basal inter-node length, extended internode length below the ear, this laid basis for the increase of photosynthetic rate of flagleaf. Spraying gibberellin at a certain concentration at wheat filling stage significantly increased 1000-grains weightand yield, while effect of Paclobutrazol was not significant. Variance analysis results showed that number of grainper ear, spikelet number and yield differed significantly among the three kinds of control agents, while infertilityspikelet and 1000-grains weight showed no significant difference.