The research aimed to study the effects of microbial ecological agent on growth performance andblood biochemical indices of meat sheep. 90 meat sheep were divided into three groups（control group, microbialecological agent group I, II）. The control group was fed with basal diet, microbial ecological agent group I, II werefed with diets added 500 mg/kg and 1000 mg/kg microbial ecological agents. Compared to control, average dailyweight gain of microbial ecological agent group I, II increased by 5.61 %（P ＜0.05） and 6.99 %（P ＜0.05）, whichfeed conversion ratio decreased by 2.68 %（P ＜0.05） and 3.13 %（P ＜0.05）, glucose increased by 5.30 %（P ＜0.05）and 5.08 %（P ＜0.05）, total proteins increased by 3.48 %（P ＜0.05） and 4.98 %（P ＜0.05）, albumin increased by 3.78 %（P ＜0.05） and 4.30 %（P ＜0.05）, urea nitrogen decreased by 5.12 %（P ＜0.05） and 5.65 %（P ＜0.05）. Thetest results showed the addition of 500 mg/kg and 1000 mg/kg microbial ecological agents could significantly im-proved the growth performance and enhanced absorption function of protein synthesis.