In recent years, corn planting area in Heilongjiang Province is continuously increasing, the weedcontrol in corn field become the most important link in agricultural production. If the control effect is poor, themaize yield will be seriously affected. In this experiment, several kinds of herbicides were used to deal with theweeds in corn field. The results showed that the control effect of Mesotrione to barnyard grass was better than Nico-sulfuron, and it could be up to 100%. The resistance of barnyard grass to Nicosulfuron in Zhaodong corn field washigher than that in Minzhu field. The control effect of Nicosulfuron was only 68.08%, and the control effect of Nico-sulfuron to abutilon theophrasti medic was worse than Mesotrione and Fluroxypyr. The total control effect of Mesotri-one mixed with Atrazine on weed was the best, it could be up to 99.41%. This can provide theoretical basis for thereasonable control of weeds in corn field.