The aim was to systematically study the prevention and control technology of peanut leaf diseaseat high latitudes. Under field conditions, setting water and carbendazim as control, Quanhua 551 was used to studythe control effect of 12 kinds of fungicides on peanut leaf spot. Results showed that 13 kinds of fungicides had pre-ventive effect against leaf spot disease, and Baitai, A-mimiaoshou, Kairun and Waier at 750.0 mL/hm², 187.5 mL/hm², 300.0 mL/hm² and 375.0 mL/hm² were better than others, which increased by 49.27%, 35.73%, 32.22% and 26.00% compared with carbendazim. Their yield were more than 5250 kg//hm², which were 15.63%, 11.84%,10.44% and 16.82% more than the water control, and 13.79%, 10.07%, 8.69% and 14.96% more than carbendazimtreatment. Also, they were safer. The results provided reference for prevention and control of peanut leaf diseaseat high latitudes.