In the study, a millet variety named ‘Fenghonggu’was used for material and the control effects of 5herbicides on weeds in the area were studied. The results suggested that different herbicides have different degreesof inhibition to weed growth. The best results on control effect were 200 g/667m²10 day after 44% Monosulfuronplus Propazine WP spraying and 25 day after 150 g/667m² of Atrazine spraying. Compared with other drugs, effectof Atrazine on plant height was more significant. The millet yield were not significant different among spraying of 2,4-D Butylate, 44% Monosulfuron plus Propazine WP and Trifluralin at 150 g/667m², but the millet yield whichsprayed of 150 g/667m² of 2,4-D Butylate was significant higher than that of spraying of 150g/667m2 of Atrazine.