Aim of this study was to explore effects of macromolecular material on wheat at seedling stage. Firstly, the macromolecular materials were modified; Second, mixed fertilizer with macromolecular materials using the overall method. And using the method of pot simulation, effect of applying modified macromolecular materials was tested by observing the plant growth index. Results showed that modified macromolecular materials that meet the requirements of the 24 modified processing were P, PO, HO. Compared with the control, the effect of modified macromolecular materials on the seedling emergence rate was not significant, which improved the seedling emergence rate by3.33%. Compared with the control, the treatment of macromolecular material and composite fertilizer improved the plant height by 18.77%, and dry matter by 10.45%. Therefore, mixed fertilizer with macromolecular materials could increase wheat seedling height, dry weight, which was conducive to the growth of wheat seedling.