At the present, there are rare relevant studies regarding tomato ulcer bacteria sensitivity to drugs. The sus-ceptibility of 19 strains of ulcer bacteria to 5 kinds of drugs was determined in the study. The results showed that all19 strains of bacteria showed tolerance to Cuaminosulfate and Thiodiazole copper, seventy three point sixty eightpercent strains of bacteria showed tolerance to Copper hydroxide, seventy eight point ninty five percent of the strainswas highly sensitive to 0.1% 2-Bromo-2-nitro-1, 3-propanediol, ninty four point seventy four percent of the strainswas highly sensitive to streptomycin. Therefore, the effect of streptomycin was far better than the effect of copperagents and Bronopol for prevention and cure of tomato canker. The emergence of resistant strains showed that the ul-cer bacteria resistance has occurred, and the strongest resistance was to copper preparation.