Objective of the study was to explore the effect of housefly maggot meal on IgG and IgE of Trichinella spi-ralis infected gerbils. At first, animal models of Trichinella spiralis was established. The experiment included follow-ing groups: control group, infection group, treatment group, and housefly maggot meal group. According to the life cy-cle of Trichinella spiralis, the infection group, the treatment group and the housefly maggot meal group included 3subgroups of treatments, i.e., 7 d subgroup, 20 d subgroups and 40 d subgroup. The contents of IgG, IgE and specif-ic IgG were detected by the method of ELISA. Results showed that the specific IgG, total IgG and total IgE of all thegroups were significant higher than that of the control group at different infection stages, and they gradually in-creased with elapsed time. In the same treatments of time group, the specific IgG, total IgG and total IgE of the treat-ment groups and the housefly maggot meal groups were significant higher than that of the infection groups, which thehousefly maggot groups showed the highest value（P＜0.05）. In conclusion, the housefly maggot meal could increaseIgG and IgE, and impact on Trichinella spiralis.