To identify field prevention and control effect and optimal dose of 45% fenaminstrobin-difenoconazole-thi-amethoxam FSC on wheat wireworm, aphids, sheath blight, powdery mildew, rust and other major diseases and insectpests, field trials was conducted with wheat Zhoumai 27 as tested varieties and using 30 g/L difenoconazole FS+20%diniconazole SC as contrast, three different kind of mass ratio（40 g/10 kg, 60 g/10 kg, 80 g/10 kg） were set. The resultsshowed that after coating with 45% fenaminstrobin-difenoconazole-thiamethoxam FSC, which had no negative effectson wheat germination, emergence and other harmful effects, controlled major diseases and insect pests. The control ef-fect with coating amount 80 g/10 kg was better than that of 60 g/10 kg, 40 g/10 kg. Except the control effect to leaf rustdisease, which was lower than the contrast agents, the control effect to main diseases and insect pests and yield in-crease of wheat was better than the contrast agents in general. With 80 g/10 kg coating amount, the control effect to thewireworm, aphids, sheath blight, powdery mildew, rust was 80.76%-86.78%, 44.10%-97.87%, 80.56%-89.83%,85.23% and 90.42% respectively, yield increase was 9.07% than CK and 0.78% higher than that of the contrast agents.