Aiming to screen a suitable reagent to control the northern leaf blight of maize in field, control effects of propiconazole, azoxystrobin, propiconazole-azoxystrobin, coumoxystrobin-tebuconazole, coumoxystrobin-tebuconazole and azoxystrobin were compared through experiments. The results showed no phytotoxicity was observed tomaize after applying propiconazole at 168.8 g/ha, azoxystrobin 300 g/ha, propiconazole-azoxystrobin 196.4 g/ha,coumoxystrobin-tebuconazole 180 m L/ha, coumoxystrobin-tebuconazole 180 m L/ha and azoxystrobin 300 g/ha according to the effective component, the control effects were 77.35%, 77.11%, 78.13%, 74.60% and 80.94% respectively for two times. Considering the production factors, the reagents of propiconazole-azoxystrobin 196.4 g/ha andthe reagents of coumoxystrobin-tebuconazole 180 mL/ha and azoxystrobin 300 g/ha were suggested, and better effect was achieved before the onset or the initial infection stage for early prevention and control.