In order to improve the health and quick development of production of Agaricus bisporus in soil caved welling, according to the relevant standards of the state and industry, large-scale production technical regulation of harmless Agaricus bisporus in soil cave dwelling was set up on the basis of experiment and demonstration and combining production practice. It contained origin environment, cultivation facilities, raw and auxiliary materials, production technology, integrated control of disease and insect, and quality and safety control, and establishment of production files, etc. The regulation will provide scientific basis and technical guidance for production of harmless Agaricus bisporus in soil cave dwelling of local area.