Proso millet has high nutritional value and is one of the important grain crops in northeast China. However, there are few herbicides suitable for proso millet. In this experiment, the control effect of different herbicides and yield of proso millet were compared for selecting the herbicides suitable for proso millet in Baicheng economic zone.The test was carried out using ‘Baimi 1’as material. 12 treatments were set with 12 agents, and each agent was applied twice. The first application was used for soil treatment after sowing and before seedling come out, the second application was applied before and after the jointing. The results showed that the treatment of 5, 6, 10 and 11 were good for controlling of grassy weed, nightshade and other weeds, which had the effect of restoring the yield. Effect of treatment 5 and 6 was better and can be used in the field weeding