Abstract:The ultrafine grinding of Traditional Chinese Veterinary Medicine(TCVM) is not in pursuit of fineness, but for the cell level ground with the cell wall broken. The trial was taken with self-assembly small-sized jet milling small batch production line. The TCVM, of which the fineness and moisture were larger then 120 mesh and less then 5% respectively after pretreatment, had been superfinely grinded into cell level ultramicro powder through adjusting the classifying screen working frequency ranged from 50 to 70 Hz and compressed air temperature ranged from-4 to 4℃ in the condition of other processing parameters being constant. The results showed that: a. the ultrafine particle sizes of center(d50) of single Artemisiae Annuae Herba, Agrimoniae Herba, Polygoni Multiflori Radix, Pulsatillae Radix, Cinnamomi Cortex and their Compound Powder "Chicken Coccidiosis Powder" were 13.91μm, 15.30 μm, 15.30 μm,13.76 μm, 13.83 μm and 14.96 μm respectively, slightly exceeded 12.5μm(1000 mesh). b. the particle size distribution widths(SPAN) were respectively 2.99, 3.29, 4.13, 3.93, 2.99 and 3.00, and the SPAN was small, presented normal distribution and uniform. The optical microscopic observation showed that the ultrafine powder was in incomplete cell structure, only presented the cell debris. Furthermore, the ultrafine grinding parameters among single and compound powder of traditional Chinese veterinary medicine were similar, so the ultrafine grinding of compound powder can be used to facilitate industrial production.