Xinjiang is an important and difficult region to implement the precise poverty alleviation strategy in China. Combining rural e-commerce with precise poverty alleviation is an effective means to accelerate the poverty alleviation in the poverty-stricken areas of Xinjiang. The situation and characteristics of poor rural regions of Xinjiang and the basic situation of rural e-commerce development were elaborated in the paper. Combined with the relevance between strategy of precise poverty alleviation and rural e-commerce of Xinjiang, and embarked from the actual situation, problems were analyzed, such as poor adaptability of rural e-commerce of Xinjiang to precise poverty alleviation, lack of cognition of rural e-commerce by peasant household, and imperfect of mechanism of poverty alleviation by rural e-commerce. Countermeasures were suggested which aimed to promote the effective combination of e-commerce in rural areas of Xinjiang with precise poverty alleviation, accelerate the development of rural economy in Xinjiang, and speed up winning the battle against poverty.