Transgenic papaya has been approved by relevant departments in China, and has been applied in production for 15 years. This is an active experiment for the commercialization of genetically modified crops that can be directly consumed. In this process, The technology diffusion mechanism of transgenic Papaya has been formed, which will be the reference basis for formulating the development policy of transgenic agricultural biotechnology in the future. This paper describes the development and application of transgenic biotechnology in the research and production of papaya, analyzes the problems and causes of the current production and application advancement, and propose the reference solution.