In this experiment,Crataegus pinnatifida Bunge and Semen cassiae（3∶1） as raw material were added with accessories, and wet granulation was used to prepare granules for easy carrying. The optimum type and proportion of excipients were determined by single factor method, and the optimum preparation process was obtained by orthogonal experiment. Finally, the quality of the granules was checked. The results showed that the diluent was used as medical dextrin and the ratio of extract powder and medical dextrin was 1∶2. The wetting agent was 70% ethanol,the ratio of extract powder and 70% ethanol was 1∶1.5. The drying temperature was 50℃, and the drying time was40 min. The prepared granules had the best effect and the quality standard of granules met the requirements of pharmacopoeia.