Aiming at the problems of large amount of fertilizer application, unbalanced nutrient input, low fertilizer utilization efficiency and declined organic matter content in the rich producing areas of rice in the west of Jilin Province, a field experiment was conducted to study the effects of partial substitution of chemical fertilizer with organic manure on rice yield, nutrients absorption and translocation, fertilizer utilization efficiency and nutrient translocation efficiency under optimized fertilization（Reduced fertilizer use by 25% compared to conventional fertilization）from 2018 to 2019. The research showed that rice yield under optimum application was improved slightly by reducing fertilizer amount. When 10% of the nitrogen fertilizer was replaced by organic fertilizer（M+90%N）, rice yield arrived at the highest value with the increment of 4.5% and 5.6% than conventional fertilization（FP） treatment, and there was significant difference in rice yield. Net income of fertilizer was increased by 1 609 yuan/ha. The efficiency of optimum fertilization was also higher than that with FP treatment, and M+90%N treatment was the best. Com-pared with FP treatment, fertilizer agronomic efficiency, fertilizer partial factor productivity and fertilizer utilization efficiency with M+90%N treatment were increased by 28.1% and 16.2%, 28.9% and 17.3%, 25.7% and 29.7%, respectively. Optimum application treatments improved N, P, K accumulations of rice, nutrient absorption and utilization and translocation efficiency compared to FP treatment.