Pot culture and field experiment were used to screen out the suitable insecticides and dosages for controlling Eriochloa villosa in soybean field. 96% s-metolachlor EC had a certain control effect on E. villosa, and the control effect in the field was 75.24%, which was 11.65% higher than that in the no-weeding area. The best effect of stem and leaf treatment on E.villosa was haloxyfop-r-methyl 10.8% EC, both pot experiments and field trial were more than 96%, the soybean yield increased significantly with increasing rate of 56.62%. Clethodim 24% EC and quizalofop-p-ethyl 15% EC also had a certain control effect on E. villosa. For the control of E. villosa in soybean field, 96% s-metolachlor EC can be used for soil sealing treatment after sowing and before seedling, and 10.8% haloxyfop-r-methyl EC after seedling has the best control effect on E. villosa.