Aiming at the current situation that wolfberry aphids were resistant to conventional pesticides and difficult to control, 5 kinds of insecticides were selected to carry out field efficacy tests. The results showed that,0.5%matrine aqueous solution 800 times liquid, 10% flulidinamide aqueous dispersible granule 3 000 times liquid and 10% cyananamide dispersible oil suspension 800 times liquid had better control effect on wolfberry aphids, and have certain quick-acting and sustained effect. The control effects of the three agents were 54.49%, 59.04% and 62.75% at 1 day after administration, 88.83%, 78.19% and 76.73% at 15 days after administration, respectively.The control effects of the three agents were higher than 20% dinotefuran soluble tablets 800 times liquid and 70%imidacloprid aqueous dispersive tablets 7 000 times liquid. The control effects of these two agents on 1 day and 15 days were 29.14%, 54.49% and 32.63%, 28.70%, respectively. Flonicamid and Cyantraniliprole can be used as a medicament for controlling aphids. Matrine is a biopesticide, widely used in agriculture in recent years, and has good control effect, can be used as green control of wolfberry and aphids in the early stage of prevention.