Three-year field experiments in west semi-arid area of Jilin Province were carried out to study the effect of different fertilization modes on maize yield and soil fertility, which provides reference for local soil improvement and fertility cultivation. The experiment was carried out in Zanzi Township, Qian’an County, Jilin Province with 6 treatments, including traditional application（Tra）, organic manure amendment（Tra+M）, subsoiling（Tra+S）, Al₂（SO₄）₃ modifier（Tra+Al）, high fertilizer application（HNPK）, integrated optimize（Opt）. The results indicated that the Opt treatment effect was the best, followed by Tra+M treatment effect in five treatments. Compared with Tra treatment,maize yields in the Opt treatment increased by an average of 11.84% over three years, soil available N, P and K at two soil layers of 0-20 cm and 20-40 cm in the Opt treatment increased by 51.3% and 41.4% on average, among which P and K increased by a higher proportion. Soil bulk density decreased by 21.6% and 14.4%, the soil three phase ratio was further optimized. To sum up, the Opt treatment were full tillage fertilizer at the soil layers of 0-40 cm, then improve the quality of maize population to achieve high and stable yield.