The development of high starch maize can effectively improve the economic benefits.Effect of the combined fertilizers application on grain yield and qualities of high starch maize was studied in Anyang,He’nan Province from 2015 to 2016.The results indicated that the yield of the non-fertilizer treatment was the lowest,the yield of maize with the single N fertilizer treatment was higher than that of non-fertilizer treatment,the yield with the N and P fertilizer combined application was higher than that with the single N fertilizer,the yield with the N,P and K fertilizer combined application was higher than that with N and P fertilizer combined application.The bigger the combined application of N,P and K fertilizers was,the higher yield was.In the period of filling-grain,the contents of starch,lipid and protein with the single N fertilizer treatment were increased than that of non-fertilizer treatment,the content of the starch of maize with the N and P fertilizer combined application was increased in the early stage and reducer in the late stage than that with the single N treatment.At the same time,the contents of lipid and starch were reduced.The contents of lipid with the N,P and K fertilizers combined application were higher than that with N and P fertilizers combined application,the contents of starch and protein was reduced.The contents of starch,lipid and protein with the low-fertilizer treatment were high in the early stage.The contents of starch with the highfertilizer treatment were increased,and the content of protein and lipid were increased in the early stage while was reduced in the late period.The best fertilizer application scheme was N for 15 kg/667 m²,P₂O₅ for 7.5 kg/667 m².