In order to determine the safety to sorghum and control effect on head smut of Ipconazole·Metalaxyl FSC（I·M FSC）, it was verified by pot experiment and field control efficacy test. The results showed that the 4.23% I·MFSC increased the emergence rate by more than 4% compared with CK. It is beneficial to the root development at seedling stage, and the root number and root length are significantly different from CK. The control effect of sorghum head smut in the field was 72.0%-82.0%, which was 6.8%-10.2% higher than CK. Through comprehensive comparison, 4.23% I·M FSC can be used to control sorghum head smut, and the appropriate dosage is the ratio of medicament to seed of 400 m L/100 kg.