In order to explore the association between polymorphism of the aryl hydrocarbon receptor（AHR） and growth traits in Large White, high resolution melting analysis（HRM）was used for genotyping, and correlation analysis was carried out in combination with growth traits in this research. The DNA samples of the ear tissue from 246 Large White were extracted. After PCR amplification, the polymorphic sites in AHR were searched by mixed pool sequencing. The primers designed for the polymorphic loci were used to test for polymorphism by HRM, and the results were correlated with the growth traits data. The results showed that a mutation site 38,332 C＞T, two alleles C and T, and three genotypes CC, CT and TT were detected in the AHR gene. The χ² suitability test showed that the genotype frequency and allele frequency of this site were significantly different among the populations, which was not consistent with the Hardy-Weinberg equilibrium law（P＞0.05）. According to population genetics analysis, this site was moderately polymorphic（0.25≤PIC≤0.5）. The mutation site of 38,332 C＞T had a significant effect on the 6-month-old body weight and average daily weight（P＜0.05） in the association analysis with growth traits. In summary,the mutation site of 38, 332 C＞T in AHR gene had a certain influence on the growth and development of Large White, which would provide a reference for Large White breeding.