In order to study the optimum NPK, Ca and Mg application amount in high-yield and high-quality conditions of tomato in bag in solar greenhouse, the three-factor and five-level experimental design was used to establish a ternary quadratic mathematical model, which independent variables were NPK, Ca and Mg, the dependent variables were yield and quality. The results showed that the fertilization schemes of tomato yield 4,300 g/plant under the conditions of this experiment were: NPK 6.994-7.220 g/plant each time, Ca 0.862-1.059 g/plant each time, Mg 0.217-0.252 g/plant each time; the fertilization schemes with a comprehensive quality score over 90 were: NPK 6.241-6.759 g/plant each time, Ca 0.654-0.868 g/plant each time, and Mg 0.204-0.246 g/plant each time. In summary, fertilization scheme of high yield（4,300 g/plant） and high quality（comprehensive score over 90） of tomatoes were NPK 6.241-6.759 g/plant each time, CaO 0.862-0.868 g/plant each time, MgO 0.217-0.246 g/plant each time, and the appropriate proportions of NPK, CaO and MgO was 1:0.13:0.03.