In order to make clear the toxicity and control effects of different neonicotinoid insecticides on Pear psylla, the toxicities of seven insecticides on nymphs of Pear psylla were determined by dipping method in laboratory, field control effects were determined using spray method in pear orchards. The results of laboratory toxicity experiments showed that the toxicity of Acetamiprid and Nitenpyram was higher with LC₅₀ of 16.4064 mg/L and 17.0297 mg/L, respectively. Thiacloprid had the lowest toxicity, and its LC₅₀ was 215.4731 mg/L, the others were ranked from larger to smaller as Dinotefuran, Imidacloprid, Clothianidin and Thiamethoxam. The field experiment results showed that the control effects of Thiamethoxam, Nitenpyram and Acetamiprid could effectively control the harm of Pear psylla, and they were performed rapid effect in killing Pear psylla and had a lasting validity period.Thiamethoxam had the best control effect, which was above 95% in the investigation period, Clothianidin and Imidacloprid had the medium control effects against Pear psylla. However, control effects of Dinotefuran and Thiacloprid were relatively poor. In the Integrated Management of Pear psylla, Thiamethoxam, Nitenpyram and Acetamiprid should be preference and used alternately to improve the control effect and delay the development of resistance according to the occurrence dynamic of Pear psyllid.