To determine the control effect of four herbicides with soil treatment against Orobauche cumana and evaluate their safety to tobacco.Field plot assay were carried out to compare the control effect and the risk of damage about four herbicides with soil treatment against O.cumana.There were significant different control effects of four herbicides against O.cumana at different doses,among them,metolachlor 72% EC has the best control effect and the less injury which can be recovered at the later stage of tobacco.The average plant and fresh weight control effect in four doses of metolachlor before harvest were from 65.40% to 77.21%,and from 58.88% to 83.28%,the average plant and fresh weight control effect of metolachlor at the dose of 150 mL/667 m² were the best,which were as 77.21% and 83.28%,respectively,followed by those at 125 mL/667 m² and 100 mL/667 m².Metolachlor 72% EC can be used to control O.cumana by soil treatment before tobacco seedling transplanting at the doses from 120mL/667 m² to 150 mL/667 m².