Experiments on control effects of pre-emergence on maize in the drip irrigation under mulch combined with the integration of water, fertilizer and pesticide were carried out in field. The results showed the atrazine, acetochlor, propisochlor, and 2, 4-D-isooctylester had effect on corn field weeds, and their control effects and fresh weight control effects of weeds were 87.35%, 87.87%, 53.44%, 82.26% and 87.38%, 87.59%, 52.26%, 83.92%, respectively after 45 days spraying. The mixture of atrazine+acetochlor, atrazine+propisochlor, atrazine+acetochlor+2,4-D-isooctylester, atrazine+propisochlor+2,4-D-isooctylester could enlarge the herbicide controlling spectrum and improve the control effect in the same time, and their control effects and fresh weight control effects were 90.35%, 87.75%, 95.86%, 93.87% and 89.98%, 87.65%, 94.65%, 93.01%, respectively after 45 days spraying.Meanwhile, it could increase the production of maize by 13.82%-27.51%.