In order to screen new tobacco varieties suitable for tobacco planting and production in Jilin Province, the adaptation of six new tobacco varieties（Longyan101, PVH1452, NC102, Yunyan301, JY2108, JY2105） was carried out in the tobacco planting base of Dunhua City, Jilin Province. For analysis, Jiyan9 was used as the control group.Comparative indicators include agronomic properties, economic properties, chemical composition and quality evaluation of flue-cured tobacco. The results show that JY2108, Yunyan301 and JY2105 perform well in the tobacco areas of Jilin Province and can be further promoted and investigated.