In order to explore the local varieties of potato drought resistance, the pot experiments were done with materials of potato Favorite and Houqihong. The results showed, firstly, the height of Favorite and the leaves' number of Houqihong had more drop in them. The yield of Favorite fell 22% and 17% as more obvious yield of a plant were declining in the two varieties of potato, and in. Secondly, the net photosynthetic rate, transpiration rate and stomatal conductance of Favorite were significantly decreased, and the net photosynthetic rate and stomatal conductance of Houqihong potato were decreased, while the intercellular CO₂ concentration and water use efficiency were keep the control level both of them. Conclusion, yield of the two varieties showed decrease under drought stress, at the same time, the photosynthesis and water metabolism were inhibited. Favorite had a lower drought resistance comparing with Houqihong because of their lower transpiration rate and water metabolism slowed down.