In order to save the cost and increase the efficiency of industrial hemp and protect the black land, the test was designed with orthogonal randomized block on the variety, density and fertilizer, and the correlation analysis was carried out. The results showed that the optimal combination of Qingma 1 was treatment 6 that density was 500plants per square meter and fertilizer dosage was 700 kg/ha and retted stem yield was 9,916.67 kg/ha. The optimal combination of Jima 1 was treatment 2 which density was 400 plants/m² and fertilizer dosage was 600 kg/ha and retted stem yield was 9,944.44 kg. The optimal combination of Huoma 1 was treatment 3 which density was 400 plants/m² and fertilizer dosage was 700 kg/ha and retted stem yield was 8,916.67 kg/ha. Treatment 2 was the best economic benefit that density was 400 plants/m² and fertilizer dosage was 600 kg/ha for saving fertilizer and seed.