On the basis of theoretical exploration of East-West industrial collaboration, the mechanism of EastWest industrial collaboration to help rural industrial revitalization is proposed, i.e., East-West industrial collaboration provides impetus for rural industrial revitalization by extending the traditional advantageous rural industry chain, enriching the rural industry categories and stimulating the vitality of factors, forming clusters and other ways.Through displaying and analyzing the practice mode of industrial collaboration between Zhejiang and Sichuan provinces, we propose the path to enhance the effect of collaboration, including accurate positioning of characteristic industries, utilizing the platform of East-West collaboration, creating industrial regional brands, and innovating green development, etc., aiming to further enhance the efficiency and level of rural industrial collaboration.